Quantitative Analysis of APIs in Blending Mixtures and Tablets

Pharmaceutical tablets consist of an Active Pharmaceutical Ingredient (API) with excipients including fillers, binders, and lubricants which are blended together to form a homogenous mixture. Blending process control is very important for final tablet quality, but detection or characterization of raw material variations and final blend homogeneity can be very challenging. In this app note, blend homogeneity is quantified using a portable Raman spectrometer combined with chemometric software from B&W Tek.

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