The performance of handheld Raman instrumentation has improved dramatically with the release of the NanoRam® because of its ability to test far more complex compounds, and differentiate between different binding/tableting materials used in the pharmaceutical industry like cellulose, microcrystalline cellulose, and hydroxypropyl methylcellulose (HPMC). Historically, identification of these types of compounds have only been achievable using research-grade, laboratory systems, which offer high resolving power and better signal to noise capability. The inherent problem is that the Raman characteristics of cellulose materials and saccharide-based food additives are not distinctive enough due to the high fluorescence nature of compounds like HPMC. The challenge that the industry currently faces using traditional handheld Raman systems is relatively poor selectivity and extremely long testing times, which leads to reliability problems and inconsistencies in the testing methods.
In this article we set out to demonstrate that the recent technological breakthroughs in the NanoRam are proving that high performance Raman spectroscopy can be combined with simplicity and ease of use in a compact design. To exemplify this, we carried out an investigation using the NanoRam handheld Raman spectrometer to see if it could differentiate between a group of different cellulosic materials and food additives.
This study was recently published in Volume 15 Issue 7 of American Pharmaceutical Review under the title “The Benefits of a High-Performance, Handheld Raman Spectrometer for the Rapid Identification of Pharmaceutical Raw Materials”. Click here to read the full article: http://www.americanpharmaceuticalreview.com/Featured-Articles/126738-The-Benefits-of-a-High-Performance-Handheld-Raman-Spectrometer-for-the-Rapid-Identification-of-Pharmaceutical-Raw-Materials/
Additionally, a shorter application note was created based off of this study which can be found here.