pharmaceutical pill bottles next to iraman spectrometer blended with chemistry formula

API Quant

Raman spectroscopy has proven valuable in quantitating active substances in pharmaceutical formulations and finished products, measuring of crystallinity, and also quantifying the concentration of different polymorphic forms and formations of chemical species (drug substances) in reactions. Because active pharmaceutical ingredients (APIs) tend to be materials with very strong Raman signals (while excipients and fillers are not always "as strong" Raman scatterers) the concentration change of the API can be detected and a calibration model of the signal of the API with concentration can be developed and used to quantitatively measure the level of APIs in new samples.

It is important to measure the quantitative measurement of APIs in pharmaceutical products in order to verify the quality, safety and authenticity of drug products. Raman spectroscopy has the advantage of being able to make measurements on solid samples directly, or through transparent materials, so products in blister packs or formulations in glass vials can be measured. With a Raman spectrum including information about the full samples matrix measured, it can be used for multicomponent analysis from a single measurement.

Products

i-Raman®

High Resolution TE Cooled Fiber Optic Raman System

i-Raman® high resolution Raman spectrometer by B&W Tek

i-Raman® Plus

Highly Sensitive, High Resolution Fiber Optic Raman System

i-raman_plus200

i-Raman® Pro

Deep Cooled, Highly Sensitive, High Resolution Fiber Optic Raman System

iramanpro_screenshot2_200px

i-Raman® Pro-ST

Portable Raman Analyzer for Rapid Analysis and Identification Through Opaque Barriers

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i-Raman® EX

1064nm Fiber Optic Raman System

i-RamanEX_200

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Application Notes

Pharmaceutical tablets consist of an Active Pharmaceutical Ingredient (API) with excipients including fillers, binders, and lubricants which are blended together to form a homogenous mixture. Blending process control is very important for final tablet quality, but detection or characterization of raw material variations and final blend homogeneity can be very challenging. In this app note, blend homogeneity is quantified using a portable Raman spectrometer combined with chemometric software from B&W Tek.
Read the full application note
Raman is a well-developed spectroscopic tool for molecular identification and is widely accepted for qualitative analysis where it can provide rapid identification of materials, often at their point of use or delivery. Due to the high resolution that Raman can provide, it is also used for structural elucidation as well as quantitative analysis
Read the full application note
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