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polymorph molecules

Polymorphs

Crystalline materials may exist in different crystalline forms, or polymorphs, which though chemically identical, have a different molecular arrangement in their crystal structure. Polymorphs often exhibit different physical and electrical properties, and can affect solubility and bioavailability, especially important for drug products (APIs). Polymorphs exist in many crystalline formation process including drug products, polymers, minerals, pigments and other chemical or biomedical reactions.

Raman scattering is very sensitive to crystal form and can be used for the proper characterization of the polymorphs. Distinctive spectral differences are often observed, and Raman can be used as a rapid screening tool for polymorph identification. Raman spectrometers are used to identify the crystal conversions by monitoring polymorph transitions in real-time for process applications. In crystallography, Raman technology is used to predict the orientation growing status through the ratio of Raman peak intensities and changes in peak positions.

Products

i-Raman® Prime

High throughput, Highly Sensitive, High Resolution Raman System

STRam®

Portable Raman Analyzer for Rapid Analysis and Identification Through Opaque Barriers

i-Raman® Pro

Deep Cooled, Highly Sensitive, High Resolution Fiber Optic Raman System

i-Raman® EX

1064nm Fiber Optic Raman System

i-Raman® Plus

Highly Sensitive, High Resolution Fiber Optic Raman System

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Application Notes

Raman spectroscopy is a nondestructive and highly versatile technique for analysis of chemicals, both organic and inorganic. It is used in industry, bioscience, medical diagnosis, forensics, and many other areas.
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Raman spectroscopy is a widely used physical characterization technique in the pharmaceutical industry. In particular, Raman spectroscopy is used to identify different polymorphic forms.
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Raman spectroscopy is used for material characterization by analyzing molecular or crystal symmetrical vibrations and rotations that are excited by a laser, and exhibit vibrations specific to the molecular bonds and crystal arrangements in the molecules. Due to its excellent spectral specificity, Raman technology is a valuable tool in distinguishing different polymorphs, and can also be used in the study of solvate forms.
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Raman Spectroscopy is an advantageous analytical tool that allows for the measurement of molecular structure and identifying chemical composition of materials based on the rotational and vibrational modes of a molecule. Access to lower frequency regions with Raman spectroscopy provides key information for applications in protein characterization, polymorph detection and identification, along with material phase and structure determination.
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Moving identity verification of incoming raw materials out of the laboratory and into the warehouse through the use of handheld spectrometers The benefits of Raman spectroscopy are well recognized for the molecular identification of unknown samples and being used routinely in various applications areas
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Raman spectroscopy is a well-suited spectroscopic technique for process development and control within development laboratories in chemical, pharmaceutical and other industries. This article demonstrates the utility of portable Raman spectroscopy as a simple and versatile tool for process analytical technology (PAT) in regards to raw material identification, in-situ monitoring of reactions in developing active pharmaceutical ingredients (APIs), and for real-time process monitoring.
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Vibrational spectroscopy is a well-established, powerful tool for polymer characterization. In this application note, we’ll explore how aqueous based water-soluble polymers(10-20% solids) can be rapidly and easily measured using the i-Raman EX portable Raman spectrometer.
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