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polymorph molecules


Polymorphism is the ability of one material to exist in more than one crystal structure and can be found in any crystalline formation process including polymers, minerals and other chemical or biomedical reactions. Raman spectrometers are used to identify the crystals respectively by monitoring polymorph transitions at-line in pharmaceutical PAT applications for further process control without delay. In crystallography, Raman technology is also used to predict the orientation growing status through the ratio rate of Raman peak intensities in different positions.



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Application Notes

Raman spectroscopy is a nondestructive and highly versatile technique for analysis of chemicals, both organic and inorganic. It is used in industry, bioscience, medical diagnosis, forensics, and many other areas.
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Raman spectroscopy is a widely used physical characterization technique in the pharmaceutical industry. In particular, Raman spectroscopy is used to identify different polymorphic forms.
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Raman spectroscopy is used for material characterization by analyzing molecular or crystal symmetrical vibrations and rotations that are excited by a laser, and exhibit vibrations specific to the molecular bonds and crystal arrangements in the molecules. Due to its excellent spectral specificity, Raman technology is a valuable tool in distinguishing different polymorphs, and can also be used in the study of solvate forms.
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Raman Spectroscopy is an advantageous analytical tool that allows for the measurement of molecular structure and identifying chemical composition of materials based on the rotational and vibrational modes of a molecule. Access to lower frequency regions with Raman spectroscopy provides key information for applications in protein characterization, polymorph detection and identification, along with material phase and structure determination.
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Moving identity verification of incoming raw materials out of the laboratory and into the warehouse through the use of handheld spectrometers The benefits of Raman spectroscopy are well recognized for the molecular identification of unknown samples and being used routinely in various applications areas
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