App Note: In-situ Monitoring of Polymorphic Transitions using Raman

The physical and chemical performance of drugs, excipients, and packaging materials are dependent on the presence of and interaction with water vapor.  The combination of Raman spectroscopy and vapor sorption techniques allows for a more comprehensive understanding of vapor-solid interactions for pharmaceutical materials as it relates to the structural properties.  In this study, the unique combination of the iRaman® from B&W Tek with a Dynamic gravimetric Vapor Sorption (DVS) system from Surface Measurement Systems has been used to monitor the real-time transformation of δ D-mannitol (delta form) to β D-mannitol (beta form).

 Click here to read the application note.

This entry was posted in Portable Raman and tagged , , , , , , . Bookmark the permalink.