handheld raman spectrometer scanning raw material

Raw Material Identification and Verification

Raw material identification and verification is important for any industry, and a regulatory requirement for pharmaceutical manufacturers. Raman instruments provide a molecular fingerprint of samples measured and provide nondestructive identification and verification of materials such as active pharmaceutical ingredients (APIs), excipients, intermediates, and finished products. It is also a well-recognized method for compliance with the PIC/S GMP guide regarding 100% identity assurance for starting materials.

Utilizing portable and handheld Raman instrumentation, non-contact analysis can be performed through transparent containers, all while maintaining the volume and integrity of the sample.

The handheld NanoRam is specialized for material ID in the pharmaceutical industry and, can be used by non-technical users to rapidly identify samples in the lab, warehouse, loading dock or field, helping to eliminate quarantine areas and expedite materials through the manufacturing lifecycle.

Having the ease to identify samples wherever in the manufacturing environment provides efficiencies in raw material, and final product acceptance without the need for material movement or sample preparation.


NanoRam® 1064 – BWT-840000953

Handheld Raman Spectrometer


The NanoRam was the most suitable Raman instrument on the global market, significantly reducing the time spent and as a result increasing the efficiency of our API control process.

— Pharmstandard

The NanoRam is so easy to use, and we are now able to get through hundreds of samples per day, allowing us to fulfill regulatory requirements of 100% identification testing of APIs

— Hetero

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Application Notes

Ever since the European Medicines Agency (EMA) recommended that all pharmaceutical companies test every raw material that passes through their manufacturing facilities, this practice has attracted great interest in the nutraceuticals, food manufacturing, cosmetics, and agricultural industries, pushing them to strive for more rigorous and technology-oriented quality control standards.
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In recent years, Raman Spectroscopy has gained a reputation in market segments that require the rapid identification of unknown compounds, such as the testing of chemicals, measurement of pharmaceutical ingredients and characterization of polymers. 
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Competition in the pharmaceutical industry is driving drug companies to spread their manufacturing operations around the globe. Unfortunately, production delocalization results in more testing of the incoming raw materials for quality assurance, product safety and regulatory purposes, which results in an increased cost of doing business. This application note discusses the economic costs and benefits of the implementation of handheld Raman in the warehouse.
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Historically, identification of complex compounds and binding/tableting materials have only been achievable using research-grade, laboratory systems, which offer high resolving power and better signal to noise capability. In this article we set out to demonstrate that the recent technological breakthroughs in the NanoRam are proving that high performance Raman spectroscopy can be combined with simplicity and ease of use in a compact design.
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Moving identity verification of incoming raw materials out of the laboratory and into the warehouse through the use of handheld spectrometers has become an accepted method for obtaining optimal efficiency for testing.  Since multiple sites within an organization often use the same raw materials, transferring identification methods and libraries between spectrometers at receiving sites can help to ensure consistency and reliability of the materials before they reach production, all while maintaining that efficiency.
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In this article, Dr. Bülent Üstün, a senior scientist at Merck Sharp & Dohme, reasons that the most efficient means for identity verification of incoming raw materials is to move it out of the laboratory and into the warehouse.   He discusses the various elements of spectroscopic techniques including Raman spectroscopy, the differences between spectral matching (e.g. “match/no match”) vs. identity verification (e.g. “pass/fail”) and how to utilize these tools to get the best possible results. 
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When it comes to rapid material identification, there is a large variety of sampling requirements and sample forms that are specific to each situation, so flexibility in measuring samples with minimal sample preparation and handling is becoming ever more important. A handheld Raman spectrometer provides the ability to sample a material directly in its original package, or to take a small sample for testing in or close to the receiving area, providing a high ROI without introducing complexity to the raw material receiving process. This application note discusses a series of accessories for handheld Raman spectrometers that addresses these issues for a cost effective solution to rapid material identification. 
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Raman technology is known for its fast speed and convenience for material identification and verification since Raman measurements can be conducted through transparent containers without any sample preparation. This technical note showcases the NanoRam handheld Raman spectrometer for raw material identification through multiple polyethylene (PE) bags.  
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This article presents the discussion on minimizing risks in quality of pharmaceutical manufacturing using Raman spectroscopy, which provides a rapid, reliable means of testing in many different environments in manufacturing, including the loading dock.  
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In this webinar, we’ll discuss new handheld Raman technologies including the NanoRam-1064 and its effectiveness for efficient and accurate raw material control in pharmaceutical manufacturing settings.  
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This technical note is to demonstrate the ability of the NanoRam® (785 nm laser excitation) for material identification through dark brown plastic bags. Tests have been done for material identification test directly from outside dark brown polyvinyl bag using NanoRam.  
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This app note demonstrates how the NanoRam-1064 accurately identifies and verifies cellulose materials used frequently in raw material pharmaceutical settings by minimizing fluorescence.  
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This app note demonstrates the effectiveness of utilizing the NanoRam-1064 for analyzing and identifying botanical ingredients while minimizing fluorescence to provide accurate results.  
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