Handheld Raman Spectrometer
The NanoRam is a state-of-the-art handheld Raman instrument for nondestructive identification and verification of materials such as APIs, excipients, intermediates, & finished products. Compact and agile, the NanoRam can be used by non-technical users to rapidly identify samples in the lab, warehouse, loading dock or field, helping to eliminate quarantine areas and expedite materials through the manufacturing lifecycle. Utilizing Raman technology, non-contact analysis can be performed through transparent containers, all while maintaining the volume and integrity of the sample.
The NanoRam handheld Raman spectrometer facilitates fast and convenient transitions between sampling accessories for raw material identification through a variety of packaging. The NanoRam comes standard with the point and shoot, vial holder, bottle adaptor, and immersion probe accessories for optimal identification of different sample forms. These accessories allow you to measure through plastic and glass containers, take in situ measurements of liquids and powders, and measure larger containers only accessible from the top. Additionally, right angle, and tablet holder accessories are available to facilitate hands-free sampling . The NanoRam is operated with easy to follow, touch screen NanoRam OS (NOS) embedded software, which allows for identification and verification and library and method development. The NanoRam ID (NID) PC software provides a secure database for data and methods management, allowing customers to export data, generate and e-sign reports and transfer methods and libraries to other NanoRam units.
Raman spectroscopy is an approved method by the U.S. and European Pharmacopoeia, as well as the Pharmacopoeia of the People’s Republic of China. It is also a well-recognized method for compliance with the PIC/S GMP guide regarding 100% identity assurance for starting materials. NanoRam has performance validation tests to ensure system performance to the standards of the USP<858>, EP 2.2.48 and JP 2.26. The NanoRam is fully compliant with all governing regulations, including 21 CFR Part 11 and Part 1040.10, and can play an integral role in cGMP compliant facilities. B&W Tek offers a wide variety of services, including assistance with method and/or new library development as well as support with IQ/OQ/PQ implementation.
Intuitive Software – a user-friendly interface for both technical & non-technical users to make their job easier
Versatility – measure a variety of samples in a variety of environments and packaging with just one unit
Data Reproducibility – superior hardware ensures that results are consistent and reliable
Performance – robust multivariate algorithms guarantee accuracy when testing and identifying materials
- High-Brightness Touch Screen Display
- Embedded 1 & 2 Dimensional Barcode Scanner
- IP-64 Dust Tight and Splash Proof Rated Housing
- Sampling Accessories for Almost Any Environment
- Batch Scanning Option for Large Volume Operation
- Intuitive Software for Technical & Non-technical Users
- Wi-Fi & Ethernet Communication for Data Sync & Management
State-of-the-art Identification Software
The NanoRam comes standard with B&W Tek’s proprietary NanoRam OS software installed within the unit, which allows for identification and verification, library and method development, and data storage/ transfer. The NanoRam ID software is designed for use on PCs for data and methods management, allowing customers to export data and generate reports. The NanoRam ID and NanoRam OS software packages are 21CFR part 11 compliant with available IQ/OQ validation documentation for pharmaceutical customers.
Additionally, the NanoRam provides secure Wi-Fi and Ethernet synchronization capabilities with network terminals in order to optimize time and resources. NanoRam OS is capable of real time data and report transfers in order to centralize information (such as libraries, method development and final reports) in general servers.
Easy Transition Between Sample Types
The NanoRam includes a variety of sampling accessories to assist you in the measurement of various materials in the form of liquids, gels, powders, or solids under both a laboratory setting and under demanding environmental conditions. The NanoRam is designed to facilitate fast and convenient transitions between sample adaptors.
The NanoRam comes standard with the point and shoot, vial holder, and bottle adaptor accessories. Additionally, a right angle, tablet holder, and immersion shaft are available to facilitate even more flexible sampling. These accessories allow you to measure through plastic and glass containers, take in situ measurements of liquids and powders, and measure larger containers only accessible from the top or located in difficult to reach areas. More details about individual accessories are available upon request.
State-of-the-art Touch Screen
The NanoRam offers unprecedented calculation power for handheld devices, employing a fast processor optimized to operate under B&W Tek’s proprietary Nanoram OS. Within seconds, it is able to process data, manage libraries of any size, and accurately identify the materials analyzed with a new level of quality from portable devices. It is designed with the capability to run almost any calculation required in day- to-day operations, without the need to download data for post-processing.
Optimized for Raman Spectroscopy
The standard configuration for the spectrometer in the NanoRam is for a 785nm laser excitation wavelength. The Crossed Czerny-Turner optical design achieves a spectral resolution of 9cm-1, while simultaneously keeping the footprint of our NanoRam small. This brings an enormous advantage for field Raman applications.
Cooled Detector for Low-Light Level Detection
Cooling an array detector with a built-in thermoelectric cooler (TEC) is an effective way to reduce dark current and noise to enhance the dynamic range and detection limit. The graphs below show the dark current and noise for an uncooled versus cooled CCD detector at an integration time of 30 seconds. Operating at room temperature, the dark current nearly saturates the uncooled CCD. When the CCD is cooled to 18°C, the dark current is reduced by two times. This allows the spectrometer to operate at long integration times and detect weak optical signals.
Creating Raman Scatter
In Raman spectroscopy, it is essential to utilize a clean, narrow bandwidth laser due to the fact that the quality of the Raman peaks are directly affected by the sharpness and stability of the delivered light source. The NanoRam series spectrometer systems feature a patented CleanLaze technology with a linewidth < 0.3nm when equipped with our 785nm laser. This technology results in the correct center wavelength and avoids the phenomenon of “mode hopping.” In addition, the laser output power can be adjusted in the software from 10 - 100%, allowing you to maximize the signal-to-noise ratio and minimize measurement time.
Laser lifetime of 10,000 hours ensures quality data for years to come!
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